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TMS for Complex Regional Pain Syndrome

The aim of the current study is to assess the efficacy of TMS in the treatment of Complex Regional Pain Syndrome (CRPS). It is hypothesized that participants who receive TMS (Group 1) relative to sham treatment (Group 2) once daily for two days will demonstrate a greater improvement in CRPS-related pain and other associated symptomology (i.e., cognitive, emotional and physical) compared to baseline. Participants will be followed until they reach their baseline for two consecutive weeks to assess safety and duration of symptom alleviation.

  • This is a clinical trial. i
  • This study is enrolling both males and females.
  • This study is enrolling patients with age between 18 years to 70 years .
  • This study is enrolling patients with any of the following conditions:
  • Syndrome
  • Somatoform Disorders
  • Complex Regional Pain Syndromes
  • Reflex Sympathetic Dystrophy

Who can participate in the study?

Inclusion Criteria:

- Age 18-70

- Diagnosis of CRPS (complex regional pain syndrome) for at least 3 months

- Average pain level reported on Numerical Rating Scale meets entry criteria

- Ability to perform the experimental task and procedures.

Exclusion Criteria:

- MRI contraindication (metal implants or devices, claustrophobia)

- TMS Contraindication (eg metal implant or devices near the site of stimulation)

- History of epilepsy

- History of a psychological or psychiatric disorder that would interfere with study
procedures, at the discretion of the researcher.

- Neurologic illness that would interfere with brain integrity

- Current medical condition or medication use that would interfere with study procedures
or data integrity, at the discretion of the researcher.

- Currently pregnant or planning to become pregnant.

- On going legal action or disability claim.

Other Information


Stanford University


National Institutes of Health (NIH)

Redlich Pain Endowment

Rocky Mountain Foundation

The Feldman Family Foundation Pain Research Fund

Responsible Party:

Sean Mackey

Start Date:

April 24, 2017

Estimated Completion Date:

June 29, 2018

Contact Locations

Stanford Pain Management Center
Redwood City
United States
Tel: 650-725-5118