Neuroblastoma

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Neuroblastoma
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Specialty scores for Neuroblastoma

Overview

Source: In partnership with Genetic and Rare Diseases Information Center, funded by the National Center for Advancing Translational Sciences, and the National Human Genome Research Institute https://rarediseases.info.nih.gov/gard.

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Neuroblastoma

overview Question

What is neuroblastoma?

Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).  The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  It affects one out of 100,000 children.  The exact cause of this tumor is not yet known.  Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy.  Treatment depends on the size and location of the tumor within the body, as well as the child’s age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.

Date Modified: 2011-10-07T07:56:00

Presentation(s)

Neoplasm of the nervous system

Abdominal pain

Abnormality of the thorax

Anemia

Ataxia

Autosomal dominant inheritance

Bone pain

Diarrhea

Elevated urinary dopamine

Elevated urinary homovanillic acid

Elevated urinary vanillylmandelic acid

Failure to thrive

Fever

Ganglioneuroblastoma

Ganglioneuroma

Heterogeneous

Horner syndrome

Hypertension

Incomplete penetrance

Myoclonus

Neuroblastoma

Opsoclonus

Skin nodule

Spinal cord compression

Sporadic

Weight loss

medical Products

Iobenguane I 123

Trade Name: Adreview™

Indication: To be used in the detection of primary or metastatic pheochromocytomas or neuroblastomas as an adjunct to other diagnostic tests

dinutuximab

Trade Name: Unituxin

Indication: For use in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2) and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy

FDA Approved Medicines

  • FDA approved dinutuximab, sold as Unituxin, manufactured by United Therapeutics for the treatment of pediatrics with high-risk neuroblastoma ( Neuroblastoma ) in year 2015.