Following specialists treat Pituitary ACTH Hypersecretion. Help us improve our data based on your experience.
Specialty scores for Pituitary ACTH Hypersecretion
Source: In partnership with Genetic and Rare Diseases Information Center, funded by the National Center for Advancing Translational Sciences, and the National Human Genome Research Institute https://rarediseases.info.nih.gov/gard.
Cushing disease is a condition caused by elevated levels of a hormone called cortisol. It is part of a group of diseases known as Cushing’s syndrome. The signs and symptoms include weight gain around the trunk and in the face, stretch marks, easy bruising, a hump on the upper back, muscle weakness, tiredness, thin bones that are prone to fracture (osteoporosis), mood disorders and memory problems. Patients also have an increased risk of infections, high blood pressure and diabetes. Women may have irregular menses and a lot of hair in the body (hirsutism). Cushing disease occurs when a benign pituitary tumor (adenoma) or pituitary hyperplasia causes the adrenal glands to produce large amounts of cortisol. The genetic cause of Cushing disease is often unknown but some cases are caused by somatic mutations in genes involved in hormonal activity. Most cases occur sporadically in people with no family history of the condition. Rarely, Cushing disease can be inherited, either as an isolated condition or as part of a genetic syndrome (such as multiple endocrine neoplasia type 1 (MEN1) and familial isolated pituitary adenoma). Treatment generally involves surgery to remove the tumor and medications to decrease cortisol levels.
Date Modified: 2015-12-16T17:33:00
Abnormality of adipose tissue
Neoplasm of the endocrine system
Reduced bone mineral density
Abnormality of the gastric mucosa
Telangiectasia of the skin
Abnormal fear/anxiety-related behavior
Biconcave vertebral bodies
Increased circulating ACTH level
Poor wound healing
Skeletal muscle atrophy
Vertebral compression fractures